Some authors have suggested that subclinical impairment of memory functions may persist for much longer, but neuropsychological assessment lasting years after tga attack has not been performed so far. Sep 25, 2016 amnesia global transitoria agt mecanismo disfuncion del hipocampo bartsch t, deuschl g. Amnesia global transitoria enfermedades cerebrales. Markowltsch department of psychology, university of konstanz, p. Transient global amnesia journal of psychopathology. Recurrent transient global amnesia, a manifestation of ischemic cerebrovascular disease.
A incidencia na populacao geral esta estimada em 510 casos100. Galimi uo di neurologia, azienda ospedaliera della valtellina e della valchiavenna, presidio ospedaliero di sondalo so correspondence rocco galimi, uo di neurologia, aovv, presidio ospedaliero di sondalo, via zubiani 33, 23035 sondalo so, italia email. We studied the clinical characteristics of transient global amnesia tga in 277 patients with an average followup of 80 months. Box 5560 d7750 konstanz, federal republic of germany received 10 june 1982 markowitsch, h. Despite several new hypotheses concerning the pathogenesis of tga, there is still no consensus about its cause.
Current hypotheses include migraine, seizure, or transient cerebral arterial ischaemia. Le differenze sono sufficientemente significative da far ritenere l amnesia transitoria una sindrome clinica eterogenea con eziologie multiple, meccanismi diversi, e diversa prognosi. Amnesia globale transitoria transient global amnesia r. Farez4 transient global amnesia tga is a syndrome character.
Transient global amnesia in childhood transient global amnesia in childhood 19801001 00. Transient global amnesia tga is a selflimited anterograde memory loss related classically to transient ischemic attacks tia, migraine and epilepsy. Clinically, it manifests with a paroxysmal, transient loss of memory function. Transient global amnesia tga is a clinical syndrome characterized by the acute onset of anterograde amnesia the inability to form new memories. Lamnesia globale transitoria e anterograda e di solito e unamnesia retrograda che inizia improvvisamente e dura fino a 24 h. Amnesia global transitoria geriatrics, gerontology and aging. However, none of these potential mechanisms explain both the absence of other neurological signs or symptoms during tga, and its frequent precipitating activities. Many clinicians would not have encountered it, and those not familiar with its presentation can miss the diagnosis.
Patients with tga frequently ask repetitive questions reflecting disorientation and may have variable inability to recall general or personal information retrograde amnesia while the episode lasts. The person may be disoriented in regard to time and place, but can. Transient global amnesia tga is a specific stereo typed syndrome of altered behavior dominated by am nesia that occurs without other neurological symptoms. Amnesia globale transitoria malattie neurologiche manuali. For the patients and relatives it is a very traumatic event. The pathophysiology of transient global amnesia tga has been obscure since the definition of this syndrome more than 30 years ago. During an episode of transient global amnesia, your recall of recent events simply vanishes, so you cant remember where you are or how you got there. Transient global amnesia generally causes profound upset in the patients and their families although it is considered a benign condition. Transient global amnesia tga is a condition characterized by sudden onset of memory loss and confusion. Pdf transient global amnesia tga is a neuropsychological syndrome in which a sudden. Transient global amnesia symptoms and causes mayo clinic. Jul 27, 2018 transient global amnesia tga has been a welldescribed phenomenon for more than 40 years.
Send this article by email how to cite this article submit a comment. Oct 31, 2016 transient global amnesia tga is a condition characterized by sudden onset of memory loss and confusion. The syndrome occurred most frequently after age 50. Transient global amnesia tga is an intriguing clinical entity. Amnesia globale transitoria journal of psychopathology. Herein, the evidence in support of and against the. Aug 15, 2018 transient global amnesia is a sudden, temporary episode of memory loss that cant be attributed to a more common neurological condition, such as epilepsy or stroke. Longterm outcome in patients with transient global. Amnesia global transitoria diagnostico y tratamiento mayo clinic. Amnesia global transitoria medicina clinica medicina. Transient global amnesia genetic and rare diseases.
Transient global amnesia in childhood, developmental. Amnesia global transitoria sintomas y causas mayo clinic. Electroencephalographic recordings were obtained during episodes of transient global amnesia in patients. Amnesia globale transitoria disturbi di cervello, midollo. Transient global amnesia tga is a neurological disorder whose key defining characteristic is a temporary but almost total disruption of shortterm memory with a range of problems accessing older memories. The physiopathology is yet to be elucidaded and the incidence is higher in the elderly. Transient global amnesia tga is a neuropsychological syndrome in which a sudden, temporary loss of the capacity of creating new memories and a retrograde amnesia of variable intensity occur. Epidemiology, pathophysiology, clinical features and therapeutics marianna da silva rafael 1, eduarda xavier. Transient global amnesia is a sudden, temporary episode of memory loss that cant be attributed to a more common neurological condition. Fondazione istituto neurologico casimiro mondino research output. Transient global amnesia represents an episode of acute onset of transient global anterograde amnesia, with a variable degree of impairment of retrograde memory, which is not associated with any. During an episode of tga, a person is not able to make new memories. Data for all patients diagnosed with possible tga in olmsted county, minnesota, between january 1, 1985, through december 31, 2010, were retrieved from the rochester epidemiology project database.